Effects of Tolbutamide on Cardiovascular Function and Myocardial Metabolism of Intact Dogs. ∗

Summary

Tolbutamide, 40 mg/kg, was rapidly administered into the femoral vein of intact, anesthetized dogs, deprived of food overnight. One hour later the following were observed: a) a significant decrease in arterial concentration of glucose; b) a significant elevation in percent of blood glucose extracted by the myocardium without any significant change in absolute amount extracted or total amount utilized; c) no significant change in arterial concentration or myocardial extraction and utilization of pyruvate, lactate, oxygen, Na⁺ or K⁺; d) no significant deviation in cardiovascular dynamics including coronary blood flow and cardiac index.