Effect of L-Histidine on Creatine,Histidine,and 1-Methylhistidine Excretion of Normal and Vit. E-Deficient Rabbits. ∗

Summary

1. Effects of L-histidine on excretion of 1-methylhistidine, histidine, and creatine of normal and Vit. E-deficient rabbits have been studied. 2. L-histidine caused an increased excretion of histidine from animals on a normal and Vit. E-deficient diet. 3. Three rabbits on a normal diet and 2 of 3 on a normal diet + L-histidine failed to excrete 1-methylhistidine in the urine. 4. Vit. E-deficient animals excreted small amounts of histidine, but large quantities of 1-methylhistidine and creatine. 5. Vit. E-deficient rabbits fed 1% L-histidine excreted less 1-methylhistidine and creatine, but increased amounts of histidine. 6. 1% L-histidine was shown to prolong the lives of Vit. E-deficient rabbits.