Failure of Orchiectomy to Affect Degenerative Joint Disease in STR/1N Mice

Summary and Conclusions

Osteoarthritis of the knees was less frequent and severe in 16 month old female than male STR/1N mice. Orchiectomy, performed at 4-6 weeks of age, failed to reduce the amount of joint disease in males. Femur length was increased in the castrate animals.