Studies on Lipid Metabolism in Mice Treated with β-Hydroxy,γ-Betaine-Butyric Acid

Summary

Administration of DL-carnitine hydrochloride (DLC) markedly increased the oxidation of C¹⁴-palmitic acid injected as such or as the triglyceride, but did not alter total CO₂ output of fasting mice. Oxidation of C¹⁴-labeled oleic acid, glycerol, sodium butyrate or acetate, glucose, glycine or DL-leucine was not increased. Long term administration of DLC neither altered the per cent composition of the major fatty acids in epididymal lipids of non-obese mice, nor was it able appreciably to decrease the carcass lipids of gold-thioglucose obese mice.