The pulmonary reaction to B. pyocyaneus

Intra-bronchial insufflation of broth cultures of B. pyocyaneus in doses of 10-15 c.c. were more fatal than any other organism thus far used, except B. prodigiosus.

The lesion produced was that of a lobular pneumonia with intra-alveolar hemorrhage and fibrinous pleurisy. The bacilli were recovered from the heart's blood and from the lungs.

Immunization experiments were successfully carried out, increasing doses of 1 to 15 c.c. being administered. Dogs survived such doses, and developed agglutinins to B. pyocyaneus.

In animals which survived ten days or longer, areas of unresolved pneumonia and thickened pleura were the rule.