Emetic Responses of Monkeys to Apomorphine,Hydergine,Deslanoside and Protoveratrine. ∗

Summary

Apomorphine, Hydergine, deslanoside, copper sulfate, and protoveratrine A were tested for their emetic action in monkeys. Apomorphine or Hydergine, even in doses as high as 0.3 mg/kg, i.v., could not provoke vomiting in monkeys. 0.1 mg/kg i.v., of deslanoside induced vomiting lasting several hours and with a long latency in 94.5% of the monkeys. After trigger zone ablation, most of the monkeys did not vomit to deslanoside and only a few vomited to high doses of this agent.

Oral copper sulfate in a dose of 160 mg provoked vomiting in 63.6% of monkeys. After gut denervation these animals did not vomit even to 360 mg, except for one which vomited to this dose after a long latency. 83.3% of the monkeys vomited to IS μg/kg of intravenous protoveratrine A. Cardiac denervation or trigger zone ablation plus cardiac denervation influenced neither the threshold emetic dose nor the latency of this agent.