Abstract
Summary
Polyvinylpyrrolidone labelled with I131 was compared with polyethylene glycol as an indicator of net water absorption in intestinal perfusion studies. Small losses of PVPI131 in normal subjects and large losses in patients with sprue could be explained by binding of the polymer to intestinal mucus. The role of this factor in fecal PVPI131 excretion is discussed. PVPI131 is not a useful indicator of net water flux in patients with sprue.
We thank Abbott Laboratories for PVPI131 used in these studies and the Radiation Research Laboratories, State University of Iowa, for providing facilities for measurement of radioactivity.
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