Prevention by Calciphylaxis of the Progeria-Like Syndrome Induced by Chronic Dihydrotachysterol Overdosage

Summary

Experiments on rats indicate that the syndrome of chronic intoxication with dihydrotachysterol (DHT), including mortality, the Mönckeberg-type of arteriosclerosis, the loss of weight, and the loss of skin elasticity, can be prevented by repeated intraperitoneal administration of ferric hydroxide with dextran (Fe-Dex).

The experimental work on which this article is based was supported by grants from National Institutes of Health, U. S. Public Health Services and from Nat. Heart Foundation of Canada.