Renal Clearance of Polythiazide

Summary

The renal clearance of C¹⁴ labeled polythiazide, a new and highly potent diuretic agent, was studied in anesthetized dogs. The ratio for polythiazide was found to be considerably lower than for other benzthiadiazines. The low clearance of polythiazide appears to be determined by the high degree of drug binding by plasma proteins, and by extensive reabsorption in the distal segment. The experimental data indicate that polythiazide is also secreted by the renal tubule.