Cancer Induction in Hamsters by Human Type 12 Adenovirus. Effect of Age and of Virus Dose. ∗

Summary

The susceptibility of newborn hamsters to induction of sarcomas at the site of injection of human type 12 adenovirus decreases rapidly with increasing age at time of injection. For a given age at the time of injection, the incidence of tumors induced is directly proportional to the dose of virus injected. The 50% tumor-inducing dose in hamsters injected when less than one day of age lies between 0.5 and 50 MTCID₁₀₀ of adenovirus under the conditions of these experiments. Increasing the dose of virus to 1000 MTCID₁₀₀ produced one tumor among 8 hamsters injected as late as 14 days of age, but none in 3-week or older hamsters.