Do Heterologous Proteins Pass from Mother to Fetus in Cow,Cat and Guinea Pig?

Summary

Human albumin was injected into pregnant cows, and human albumin, bovine albumin, and human gamma globulin were injected into pregnant cats and guinea pigs. Subsequently, the blood and other fluids were obtained from the fetus or newborn and titrated with specific antisera against the 3 proteins. In cows near term no human albumin passed to the fetus. In cats both human and bovine albumins passed in large amounts into fetal blood and into the fluids of exocoelom, amnion, and stomach; but human gamma globulin passed to fetal serum in only small amounts and was virtually absent in the other fetal fluids. In guinea pigs, all 3 proteins were found in high titers in the fetal serum, but only traces of them were found in other fetal fluids.