Abstract
Conclusions
1. Experience with 17 dogs subjected to duodenal freezing for 10 minutes suggests that secretin release to acid stimulation of the duodenum is significantly impaired for at least 3 months. Average total response to HCl instillation in the post-freeze duodenum is 28.2% of control mean response. More prolonged periods of freezing do not result in greater depression. 2. No evidence of significant pancreatic derangement has been found to result from duodenal freezing. 3. If the duodenum is exposed to air during the freezing process, there is a significant incidence of duodenal necrosis, which was not observed with intraperitoneal freezing for 10 minutes.
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