Metabolism of Injected Na 2 S 35 O 4 in the Rat. I. Effect of Liver Injury on Serum Sulfate. ∗

Summary

The metabolic pattern of S³⁵ labelled perchloric acid soluble and insoluble serum proteins was studied following intraperitoneal administration of S³⁵O₄ in rats. During the phase of acute liver injury and cirrhosis induced by 8% protein diet containing 0.06% 3-methyl-4-dimethylaminoazobenzene, there was a significant increase in specific activity (fraction of administered dose × 10^-6/mg of protein) and a marked prolongation of the half-life time of S³⁵O₄ associated with both perchloric acid soluble and insoluble serum protein fractions. With the development of hepatomas the rate of decrease of specific activity of these protein fractions became similar to that of normals. The major portion of the total non-dialyzable S³⁵ was associated with the more abundant perchloric acid insoluble serum protein fraction in all animals studied.