Vitamin E Deficiency in the Monkey. VI. Metabolism of Greatine-1-G 14 . ∗

Summary

After creatine-1-C¹⁴ injection half-times of body creatine of 38, 40, and 51 days were found in 3 normal rhesus monkeys. Three vitamin E-deficient monkeys had shortened half-times of body creatine: 20, 21, and 23 days. This abnormality points to a defect in the ability of skeletal muscle to retain creatine as the explanation for the low concentration of creatine in muscle of vitamin E-deficient animals.