Abstract
Summary
Alkaline extracts of the whole pancreas were found to be capable of rendering about one-half the hydroxyproline content of native soluble collagen into a dialyzable form. These extracts could also solubilize small amounts of dialyzable hydroxyproline from washed insoluble collagen. This apparent collagenolytic activity of pancreas extracts was not inhibited by EDTA, soybean trypsin inhibitor or mercurobenzoate. These fractions did not demonstrate any proteolytic activity upon denatured hemoglobin.
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