Penetration of Herpes Simplex Virus into Human Epidermoid Cells. ∗

Summary

The kinetics of infective center formation was studied as a parameter of herpes simplex virus penetration into suspended HEp-2 cells. Similar rates of penetration were obtained when antibody or acid was used to inactivate virus attached to the cell surface, although the acid method was far more efficient and reliable. The data indicate that virus penetration is strictly temperature dependent and is virtually complete by 7 minutes at 37°, but the reaction does not conform to simple first order kinetics.