Abstract
Summary
Phenol 3, 6 dibromphthalein di-sulfonate has been prepared and its fate determined in vivo. After intravenous injection into rabbits it is removed from plasma at rates less than BSP. In the rat a similar but less apparent relationship may exist. Analysis of bile revealed that, unlike BSP, the new compound is not conjugated in vivo, nor was it possible to synthesize a glutathione conjugate in vitro. The new compound is useful for studies of hepatic uptake and excretion.
The author wishes to thank Dr. H. A. Brown Dunning, Jr., and Dr. Lloyd Felton of Hynson, Westcott and Dunning, Baltimore, Md., for their cooperation and generous supply of material.
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