On the Anti-Inflammatory Activity of Aminophylline

Summary

When given orally aminophylline exhibited significant inhibition of at least 3 of 4 models of increased capillary permeability in the rat paw. The sensitive models were those induced by carrageenin, dextran, and formalin. Serotonin was affected at only the highest dose level (400 mg/kg). A fourth model, ultraviolet light-induced erythema in guinea pigs, was also inhibited.

The authors gratefully acknowledge the technical assistance of N. E. Adler and J. P. Braselton.