Lactic Dehydrogenase Isozymes During Development of Azo Dye Tumors

Summary

During the administration of the hepatocarcinogen 3‘-methyl-4-dimethyl-aminobenzene changes occurred in the distribution of lactic dehydrogenase isozymes in rat liver. This new pattern persisted in those animals which were maintained on the carcinogenic diet until tumors developed. If animals were removed from the carcinogenic diet early enough to prevent the ultimate formation of tumors the altered pattern soon reverted to “normal” in most cases. However, if animals were removed from the carcinogenic diet too late to prevent the ultimate formation of tumors the altered pattern was still in evidence after these animals developed tumors.