Hadacidin Potentiation of Lethal Action of Ionizing Irradiation. II. Effect on Proliferating Gram-Negative Bacteria. ∗

Summary

It may be concluded from this work that hadacidin is a potent potentiator of the lethal effects of ionizing irradiation on proliferating cells of a number of Gram-negative organisms. It appears from preliminary studies that for hadacidin potentiation of ionizing irradiation to be demonstrated, a damaging dose of irradiation must be used and that the compound must be present either prior to or during irradiation. Our data also suggest that hadacidin potentiates irradiation damage regardless of the physiological age of the cells at the time of addition of hadacidin or the amount of time the cells are exposed to it during growth.