Abstract
Summary
The ability of 2 polyoma virus strains, 3049 and lp-D, to produce transplant immunity in adult hamsters against tumor cells induced by both strains was studied. The 3049 virus immunized hamsters against tumor cells produced by itself, but tended to enhance the growth of lp-D virus-induced tumor cells. On the other hand, the lp-D virus produced little or no immunity against its own tumor cell, but enhanced the growth of 3049 virus-induced cells. X-irradiated tumor cells induced by the 3049 virus, when given to adult hamsters, enhanced the growth of both 3049 and lp-D tumors. Possible explanations for these paradoxical results, based on the presence of at least 2 transplant antigens, were discussed.
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