Antigenicity of Polypeptides (Poly Alpha Amino Acids). XIV. Studies on Immunological Tolerance with Structurally Related Synthetic Polymers. ∗

Summary

It. has been shown that neonatal injections of the polymers G₆₀A₄₀ and G₄₂L₂₈A₃₀ can establish acquired immunological tolerance against these homologous polymers. Neonatal injections of polyglutamic acid are more effective than G₄₂L₂₈A₃₀ in establishing cross tolerance against G₆₀A₄₀. Neither polyglutamic acid nor G₆₀L₄₀ when injected neonatally. were effective in reducing an adult, response against G₄₂L₂₈A₃₀. However, G₆₀A₄₀ did reduce the response against a first course of immunization with G₄₂L₂₈A₃₀. This tolerance was broken by a second immunization with polymer in complete adjuvants.