Abstract
Summary
After 2 weeks of daily subcutaneous medication with chloroquine the order of increasing tissue concentrations in the English guinea pig was generally: plasma, muscle, heart, liver, spleen, eye, lung, and kidney. The level of ascorbic acid intake did not significantly affect the ocular concentration of the drug, nor did it significantly alter the tissue to plasma concentration ratios, except in the muscle. The apparent overall effect of ascorbic acid in significantly decreasing the tissue retention of this drug might prove to be a valuable property.
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