Abstract
Summary
Six-week-old C3H mice injected neonatally with Gross passage A leukemia virus were found to be unable to reject skin grafts across a weak histocompatibility barrier. The similarity of the defects in the immune mechanisms of these mice to those of the neonatally thymectomized mice suggests that the establishment of the oncogenic agent in the neonatal thymus results in marked functional impairment long before histologic changes are apparent.
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