Abstract
Summary
The ingestion of 0.001% F- in the diet of young rats decreased the excretion of calcium in the urine. In addition to decreasing the calcium excretion in the urine, 0.035% F- produced a marked alteration in phosphate metabolism; absorption of phosphate from the gut was increased, plasma inorganic phosphate elevated and its excretion in the urine increased. No change in bone phosphate was found. Apart from concentration of fluoride in bone and an increase in concentration of magnesium in this tissue the mineral composition was the same as in the control animals. Analysis of teeth from the rats after 61 days of high fluoride ingestion revealed a striking rise in the sodium and potassium concentration in the whole tissue.
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