Abstract
Summary
Mucopolysaccharide levels have been measured in urine specimens of normal persons, patients with Hurler's syndrome and their relatives. In the samples from normal humans a marked decrease was observed in the amount of chondroitin sulfates and muco-polysaccharides per unit of creatinine with age until the late teens, after which the amount became constant. In normal humans a decrease in the chondroitin sulfate/muco-polysaccharide ratio with increased age was also observed. After making appropriate allowances for age and creatinine levels in the urine, mucopolysaccharide excretion in parents and siblings of Hurler's patients was found to be similar to normal individuals by all criteria used. Several patients with the heparitin sulfateuria type of mucopolysaccha-ridosis were found in this survey.
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