Early Effects of SV 40 on Growth in vitro of Hamster and Human Tissue Cells. ∗

Summary

Suspensions of cells derived from hamster embryonic and lung tissues soon after exposure to SV₄₀ virus exhibited enhanced capacity to multiply in a soft agar medium. Such enhancement was not observed in human kidney cells similarly treated. Production of SV₄₀ T antigen was seen in hamster embryo cells after 3-4 weeks and in human kidney cells after 8 weeks following exposure to the virus but was not observed at 3, 5 and 8 weeks in lung cells maintained under the same conditions.