Effect of Carbon Tetrachloride on Incorporation of Linoleic-1-C 14 Acid into Liver Lipids in Rats in vivo ∗

Summary

Linoleic-1-C¹⁴ acid was rapidly incorporated into the liver lipids of both control and carbon tetrachloride treated rats. Twenty minutes after the injection, a pronounced fall in incorporation into phospha-tidyl ethanolamine with a concurrent rise in incorporation into cardiolipin and phospha-tidyl choline fractions was observed in the degenerating liver. The increased incorporation of radioactivity into cardiolipin and phos-phatidyl choline was reflected in an increased content of linoleic acid in these phospho-lipids but not in phosphatidyl ethanolamine. These results sugested the existence of separate pools of linoleic acid for incorporation into individual phospholipids.