Susceptibility of HeLa Cells in S-Phase to Inhibition of DNA Synthesis by Poliovirus Infection. ∗

Summary

The inhibition of DNA synthesis in the 4 to 5 hour interval following infection with poliovirus was the same in untreated HeLa cells as in those whose DNA synthesis had been blocked up to this point by action of FUDR. The viral mechanism which inhibits DNA synthesis can develop in the absence of DNA synthesis. The inhibitory action is directed against cells already in the DNA productive phase rather than to prevent cells from entering this phase.