Abstract
Summary
Changes in the composition of plasma triglyceride fatty acids and free fatty acids have been investigated in normal and gold thioglucose hypothalamic obese mice of the CBA and Swiss ICR strain. Significant elevations in palmitoleate were seen in plasma triglyceride fatty acids of CBA hypophysectomized gold thioglucose treated mice and in CBA gold thioglucose treated controls. Decreases in the levels of linoleate were also found in these two groups. Hypophysectomy alone did not result in changes in triglyceride fatty acid composition. An increase in palmitate and a decrease in linoleate were also seen in the plasma triglycerides of gold thioglucose treated mice of the Swiss ICR strain. The free fatty acid linoleate values were reduced by 50% in these mice. There was no significant increase in palmitoleate as seen in gold thioglucose treated CBA mice. The linoleate/palmitate ratio has been found to be a convenient index to follow changes in plasma fat composition.
We are grateful to Dr. E. B. Hershberg, and Schering Corp. Bloomfield, N. J., for their generous repeated gifts of gold thioglucose, also to Dr. James Hamilton for advice and suggestions on preparation of the manuscript. Acknowledgement is made of the excellent technical assistance of R. Howes and E. Marconi.
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