Abstract
Summary
The effect of sympathetic de-nervation of one carotid artery, iris and cornea on the rate of atherosclerosis in these structures as compared to its neurally intact partner was studied in 19 male albino rabbits fed a diet containing 0.3% of cholesterol. Animals were sacrificed after receiving the diet for 18 to 54 weeks. The levels of serum cholesterol rose at markedly different rates and to different degrees. Similarly, the extent of atherosclerosis showed large individual differences not clearly related to the degree of hypercholesterolemia. The carotid vessels were less affected than the aorta and no consistent asymmetry in lipid deposition in the carotid vessels, iris or cornea was observed following unilateral adrenergic denervation.
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