Abstract
Summary
Delayed testing is compared to concurrent testing for the evaluation of chemotherapeutic agents using samples of L-asparaginase as test materials. A large difference in the detection of the antitumor activity of the agents was found, depending upon the method of testing. Guinea pig serum L-asparaginase was quite effective in repressing tumor development when administered within an hour of tumor inoclation while an L-asparaginase (EC-2) from Esche-richia coli was not. The delayed test (treatment given 7 days after tumor inoculation) however, showed that EC-2 was able to induce complete remission of an established transplant of each of the 3 lymphoid tumors tested (EARAD1, 6C3HED, and P1798).
These results draw attention to the value of the delayed test for the screening of potential chemotherapeutic agents.
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