Experimental Studies of Factors Influencing Hepatic Metastases. XVIII. Significance of Trapped Tumor Cells. ∗

Summary

No increase in numbers of intra-portally injected ⁵¹Cr-labeled Walker tumor cells was detected in livers of rats subjected to partial hepatectomy, hepatic manipulation, reticuloendothelial blockade, high fat, choline-free diet, caval constriction, or injection of dextran. This information indicates that the augmentation of hepatic metastases produced by these modalities in this model system is related to their metabolic or biologic (“soil”) rather than mechanical influences on hepatic-tumor cell relationships.