Antioxidant Maintenance of Hepatic Triglyceride Secretory Activity And Hepatic Function in Carbon Tetrachloride Poisoned Rats. ∗

Summary

Prior administration of the lipid antioxidant, DPPD, to rats which subsequently received CC1₄ orally prevented the CCU-induced depression of plasma triglyc-eride concentration and maintained a normal hepatic release of triglyceride into the plasma compartment, as assessed by the post-Triton hypertriglyceridemic response. Administration of DPPD also prevented the CCl₄-induced impairment in the hepatic removal of BSP. These findings, coupled with prior observation of inhibition of CCU-induced hepatic fatty infiltration, hepatic necrosis, and lethality, indicate that antioxidants can modify the degree and nature of hepatic cell injury resulting from exposure to certain toxic substances.