Abstract
Summary
When neutral solutions of natural dog bile or of synthetic taurocholate labeled with chromatographically pure taurocholate-24-14C were placed in pouches of the oxyntic gland area of the dog's stomach, total radioactivity decreased. Calculated rate of absorption of taurocholate was greater the higher the concentration of taurocholate in the pouch, and it ranged from 12 to 304 μM per hour. That bile salt can be absorbed from the stomach into venous blood was shown by the fact that when the stomach of an anesthetized dog was filled with a neutral solution of 10 mM bile salts derived from dog bile and labeled with taurocholate-24-14C, radioactivity appeared in the fluid collected by cannulation of the animal's bile duct.
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