Supporting Role of Vasodilators in Inducing Regressions of the Ehrlich Solid Tumor. ∗

Summary

1. When mice bearing established, solid Ehrlich carcinomas were treated with pentaerythritol tetranitrate, there was an increase in the localization of Evans blue dye in the tumors. Epinephrine caused a decrease in the dye recovered from the tumors. 2. When mice bearing solid Ehrlich tumors were treated with pentaerythritol tetranitrate, heterologous antitumor serum (adsorbed) and normal guinea pig serum, 60% of the tumors regressed if treatment was continued for 5 weeks or longer. The administration of guinea pig serum may have been unnecessary.