Abstract
Summary
After 4 days of treatment with U-19425, rats no longer respond to the drug with a decrease in plasma FFA and blood sugar 2 hours after treatment. The initial plasma FFA response to the drug is similar, but pretreated rats escape from antilipolytic effects of U-19425 faster than nonpretreated controls. Tachyphylaxis to 5-methylpyrazole-3-carboxylic acid may be due to a physiological compensatory mechanism which is mediated by the adrenal and/or pituitary glands.
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