Abstract
Summary
Transfer studies of developing in vitro mouse bone marrow colonies have shown that the colony stimulating factor in leukemic mouse serum is required both to trigger colony formation and for continued division of colony cells. Cross reactivity of colony stimulating activity was demonstrable between the sera of leukemic Swiss, Moloney and AKR mice and human mononucleosis serum. Transfer studies have demonstrated the feasibility of cloning developing bone marrow colony cells, the cloning efficiency varying from 19 to 47%. Cloning did not lead to the renewed formation of true colonies of the type developing de novo from stimulated bone marrow cells.
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