Abstract
Summary
In hypophysectomized rats fasting reduced the metabolism of glucose in adipose tissue and diaphragm muscle in vitro and increased the mobilization of free fatty acids and glycerol. Hepatic and cardiac glycogen were also reduced. Treatment with actinomycin D reversed these effects, and caused a substantial increase in glucose utilization by adipose tissue. Actinomycin partially prevented the increased lipolysis caused by fasting in normal rats, but failed to reduce the lipolysis evoked by epinephrine or corticotropin.
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