Abstract
Summary
A comparison of the antibody response of humans vaccinated with either A2/Japan/305/57 or A2/Japan/170/62 monovalent vaccine as measured by HAdI and HI techniques has been presented. Although the HAdI antibody titers were higher the information obtained from comparisons of the frequency of antibody response and of mean fold titer increases was the same for both methods. Thus, it would appear from this experience that the HAdI technique offers no great advantage for the selection of vaccine strains when the criterion is the antibody response in man. In addition, it should be pointed out that the HAdI test is a more laborious, expensive and time consuming procedure than the HI method.
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