Effect of Mithramycin on Kidney Transamidinase of C3H Mice ∗ †

Summary

Mithramycin is an antitumor agent known to inhibit the synthesis of RNA and to produce severe renal toxicity. After 3 days of administration of mithramycin to normal mice, there was a significant decrease in kidney transamidinase activities compared to pair-fed control animals. It appears that transamidinase activity is localized in the tubular cells and the loss of enzyme activity is the result of the loss of the integrity of the kidney tubule cells.