Abstract
Summary
In biotin deficiency, energy production was impaired in two ways: by decreased utilization of glucose and by decreased oxidative phosphorylation. The decrease in the utilization of glucose was reflected in low glucose tolerance, a decrease in glycogen synthesis, and amino acid incorporation in liver proteins and an increase in the excretion of ketone bodies. Fructose or sorbitol feeding or insulin administration to the deficient animal brought about an improvement in amino acid incorporation. In biotin deficiency the lipid content of mitochondria was significantly decreased.
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