Abstract
Summary
Reabsorption of filtered blood albumin-Evans blue across proximal tubule cells was not of free molecules through cytoplasm. The blue “screen” we use to identify free dye-protein was absent. The path and timing of migration in tubular epithelium of the special Evans blue granules seen was the same as that shown by other authors for labeled proteins and for trypan blue (close chemical relative to Evans blue), which are known through electron microscopy to migrate by enclosure inside single membrane vesicles. In reabsorption, albumin-Evans blue must migrate in this same vesicle system.
Get full access to this article
View all access options for this article.