Host Specificity and Serologic Disparity of African Swine Fever Virus and Amphibian Polyhedral Cytoplasmic Viruses

Summary

Serologic tests designed to demonstrate a relationship between polyhedral cytoplasmic viruses from amphibia and African swine fever virus indicated no cross-reactivity between the agents using techniques that revealed clean homologous activity. A 3000 pig LD₁₀₀ of ASFV injected into toads susceptible to FV1 and FV3 did not cause death. Large doses of FV1 (greater than 1000 toad LD₅₀) neither produced disease signs nor stimulated the production of antibodies against ASFV in swine. The data indicate that cytoplasmic frog viruses and ASFV, which have many common properties, are not serologically related and do not share common host range.