Abstract
Summary
The stimulation of prostatic secretion by nicotine, 4-(m-chlorophenylcarbamoyloxy) −2-butynyltrimethylammonium chloride (McN-A-343) and N-benzyl-3-pyrrolidyl acetate methobromide (AHR-602) was studied in unanesthetized, castrated, testosteronetreated dogs with surgically prepared fistulas which allowed the collection of prostatic fluid uncontaminated by urine. The subcutaneous administration of 0.3, 1, or 3 mg/kg of nicotine provoked the secretion of only small amounts of prostatic fluid accompanied by tachycardia and emesis; the highest dose also produced tachypnea and relaxation of the nictitating membranes. The intravenous administration of 0.3, 1, or 3 mg/kg of McN-A-343 produced a moderate secretion of prostatic fluid accompanied by salivation, lacrimation, emesis, piloerection, and variable effects on heart rate. The intravenous administration of 1, 3, 10, or 30 mg/kg of AHR-602 produced a moderate prostatic secretion accompanied by salivation and piloerection. Atropine reduced the prostatic secretion in response to all three agents; hexamethonium reduced the secretory response to nicotine only; and cocaine did not reduce the secretory response to any of these drugs.
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