Iron and Copper Effects on Serum Ceruloplasmin Activity of Rats with Zinc-Induced Copper Deficiency ∗

Summary

The results of the two experiments conducted to determine the effects of high zinc diets on CPA were as follows: The CPA dropped precipitously in approximately 1 week. The i.p. administration of 100 μg of copper induced a significant rise in CPA. The administration of iron and copper brought about a significant rise in CPA over and above that when copper alone was administered in both control and zinc-fed groups. Copper alone had no effect on CPA of the control rats while iron alone had no effect on CPA level of the zinc-fed rats. However, iron alone increased the CPA of the control rats.