Abstract
Summary
Different groups of rats were injected with acid phosphatase, beta glucuronidase, and serotonin in the study. An hour after injection the levels of plasminogen activator and acid phosphatase activity were significantly increased above those of saline-injected control rats with the exception of acid phosphatase activity in sera of beta glucuronidase-injected rats. Simultaneously, the lysosomal fractions isolated from the liver of these rats showed a significant decrease in plasminogen activator and acid phosphatase activity as compared with those of saline-injected controls. These enzymes may be helpful as experimental inducers of plasminogen activator release from cellular lysosomes into the blood vascular system in higher animals.
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