Differences in Nuclear Ribonucleic Acid of Human Neoplastic and Normal Tissue ∗

Summary

We observed definite and consistent differences between RNA isolated from neoplastic and normal human tissue by electrophoresis on polyacrylamide gels. The major differences were in the nuclear RNA preparations; here the preparations from neoplastic tissue contained several fractions not found in those from normal tissue. Only minor differences were detected in the RNA patterns of cytoplasmic preparations.