A Strain Difference in 2,5-Di- tert -butylhydroquinone (DBH) Toxicity in the Mouse

Summary

A significant difference in response between mice of the CD-1 and C3H/HeJ strains was observed on purified diets containing DBH. With mice of the CD-1 strain no adverse effects on either weight increment, survival or gross appearance were observed over a 16-week period on purified diets containing 0.25 and 0.5% DBH. In the case of mice of the C3H/HeJ strain 5 out of 20 mice fed the purified diet containing 0.25% DBH and 18 of 20 mice fed the purified diet containing 0.5% DBH died during days 5-7 of feeding.