Abstract
Summary
By injecting mice with PTU to block synthesis of endogenous thyroid hormone, and by injecting graded dosages of L-thyroxine for a 20-day period, the estimated normal TH level of these blocked animals was determined. Using Klebsiella pneumoniae as an acute infective agent, it was demonstrated that the hypothyroid state increases host resistance, whereas any increase in L-thyroxine decreases resistance. Several possible mechanisms are discussed.
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